Phenazepam should not be taken with alcohol or any other CNS depressants. Phenazepam should not be used therapeutically for periods of longer than one month including tapering on and off the drug as recommended for any benzodiazepine in the British national …

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By the force of tranquilizing and anxiolytic (antianxiety) action is superior to other benzodiazepine tranquilizers and abenzodiazepinovye; It has also expressed an anticonvulsant, muscle relaxant (muscle-relaxing) and sedative effect. Average daily dose of phenazepam is 1.5 - 5 mg, it is separated into 2-3 doses : usually 0.5-1 mg in the morning and in the afternoon , at night - up to 2.5 mg . The maximum daily dose is 10 mg.For sleep disorders the drug should be used at a dose of 0.25-0.5 mg for 20 - 30 minutes before sleep. Description. Phenazepam is a benzodiazepine agonist of the γ-aminobutyric acid A (GABA)-benzodiazepine receptor chloride channel complex. It has been shown to have strong anxiolytic, sedative, anticonvulsive, and hypnotic properties in humans as well as in animal species when administered at 1 mg/kg.

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Phenazepam pharmacokinetics in humans differs significantly from that of rats, cats, and dogs. 3-OH-phenazepam was not detected in human blood at any time after administration. However, its presence cannot entirely be ruled out as the the analysis techniques used by Zherdev (1982) only tested for the presence of 3 ng/ml or more, and 3-OH-phenazepam was detected in urine [29] .

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